Contribution information
| Title | Homogeneous Pd-catalyzed Heck coupling in gamma-valerolactone as a green reaction medium |
| Status | Accepted |
| Final type | Lecture |
| Final session | Reaction engineering and catalysis |
| Authors |
L., Mika1,
J., Tukacs2,
D., Fodor3,
T., Kegl4,
A., Horváth5
1 Budapest University of Technology and Economics, Budapest, Hungary
2 Budapest University of Technology and Economics, Budapest, Hungary
3 Budapest University of Technology and Economics, Budapest, Hungary
4 University of Pecs, Pecs, Hungary
5 University of Pécs, Pécs, Hungary
|
| Uploaded abstract | link |
| Brief content | We have shown that gamma-valerolactone can be used as a media for phosphine-free Pd-catalyzed synthesis of several stilbene derivatives. In addition, a simplified kinetic model was proposed to model the reaction and determine key thermodynamic parameters of the transformation in GVL. The kinetic study was supported by theoretical DFT calculations, as well. The kinetic model reveals H‡app = 103.1 kJ·mol–1 for the apparent overall activation enthalpy of the reaction when GVL is used as a solvent, and H‡app = 103.7 kJ·mol–1 in case of DMF. Because no significant difference between the reaction efficiencies in NMP and GVL was observed, the latter can be used as a reaction medium for this purpose. |
| ID | 308 |